Article
Genome rearrangement in top3 mutants of Saccharomyces cerevisiae requires a functional RAD1 excision repair gene.
Molecular and cellular biology - 1 Nov 1992
Bailis A M, Arthur L, Rothstein R
Abstract excerpt
Saccharomyces cerevisiae cells that are mutated at TOP3, a gene that encodes a protein homologous to bacterial type I topoisomerases, have a variety of defects, including reduced growth rate, altered gene expression, blocked sporulation, and elevated rates of mitotic recombination at several loci. The rate of ectopic recombination between two unlinked, homologous loci, SAM1 and SAM2, is sixfold higher in cells...
Topics
- Cell Division
- DNA Repair
- DNA Repair Enzymes
- DNA Topoisomerases, Type I
- DNA-Binding Proteins
- Endonucleases
- Fungal Proteins
- Genes, Fungal
- Kinetics
- Mutation
- Phenotype