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Article

Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila.

Neuroscience letters - 23 Jan 2003

Takahashi Makio, Kanuka Hirotaka, Fujiwara Hideo, Koyama Akihiko, Hasegawa Masato, Miura Masayuki, Iwatsubo Takeshi

Abstract excerpt

alpha-Synuclein is a major component of Lewy bodies in the brains of patients with Parkinson's disease (PD) as well as of neuronal/glial inclusions in a subset of neurodegenerative disorders collectively termed synucleinopathies. Here we studied by immunohistochemistry the accumulation of alpha-synuclein in transgenic (TG) Drosophila overexpressing wild-type (WT) or familial PD-linked mutant (i.e. A30P and A53T)...

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PMID: 12505616
DOI: 10.1016/s0304-3940(02)01258-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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