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Article

Transgenic Models of α‐Synuclein Pathology

1 Jun 2003

Abstract excerpt

Accumulation and toxic conversion to protofibrils of alpha-synuclein has been associated with neurological disorders such as Parkinson's disease (PD), Lewy body disease, multiple system atrophy, neurodegeneration with brain iron accumulation type 1, and Alzheimer's disease. In recent years, modeling these disorders in transgenic (tg) mice and flies has helped improve understanding of the pathogenesis of these...

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PMID: 12846986
DOI: 10.1111/j.1749-6632.2003.tb07475.x

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