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Article

Transgenic mice expressing S129 phosphorylation mutations in α-synuclein.

Neuroscience letters - 20 Mar 2014

Escobar Valerie Drews, Kuo Yien-Ming, Orrison Bonnie M, Giasson Benoit I, Nussbaum Robert L

Abstract excerpt

Aggregated α-synuclein is a predominant constituent of Lewy bodies, the intracellular protein aggregates seen in Parkinson's disease. While most α-synuclein in the nervous system is unphosphorylated, the majority of α-synuclein in Lewy bodies is phosphorylated at serine 129 (S129). We developed transgenic mice expressing human SNCA with either a phosphomimic (S129D) or a non-phosphorylatable (S129A) mutation, on...

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Identifiers

PMID: 24486885
DOI: 10.1016/j.neulet.2014.01.033
PMCID: PMC4059511

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Transgenic mice expressing S129 phosphorylation mutations in α-synuclein.PMID 24486885Read ↗

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