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Article

Distribution of allelic and genotypic frequencies of NAT2 and CYP2E1 variants in Moroccan population.

BMC genetics - 29 Dec 2014

Guaoua Soukaina, Ratbi Ilham, Laarabi Fatima Zahra, Elalaoui Siham Chafai, Jaouad Imane Cherkaoui, Barkat Amina, Sefiani Abdelaziz

Abstract excerpt

BACKGROUND: Several pathogenesis and genetic factors influence predisposition to antituberculosis drug-induced hepatotoxicity (ATDH) especially for isoniazid (INH). However, the major susceptibility genes for ATDH are N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1). NAT2 gene determines the individual's acetylator status (fast, intermediate or slow) to metabolize drugs and xenobiotics, while CYP2E1...

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Share to Antitubercular Agents
Share to Arylamine N-Acetyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemical and Drug Induced Liver Injury

Share to Cytochrome P-450 CYP2E1

Share to Infant, Newborn

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Source

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Identifiers

PMID: 25544508
DOI: 10.1186/s12863-014-0156-x
PMCID: PMC4299568

Genes

NAT2

Provenance

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