Article
Absence of IL-4 facilitates the development of chronic autoimmune myasthenia gravis in C57BL/6 mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2003
Ostlie Norma, Milani Monica, Wang Wei, Okita David, Conti-Fine Bianca M
Abstract excerpt
Myasthenia gravis (MG) is a T cell-dependent, Ab-mediated autoimmune disease. Ab against muscle acetylcholine receptor (AChR) cause the muscular weakness that characterizes MG and its animal model, experimental MG (EMG). EMG is induced in C57BL6 (B6) mice by three injections of Torpedo AChR (TAChR) in adjuvant. B6 mice develop anti-TAChR Ab that cross-react with mouse muscle AChR, but their CD4+ T cells do not...
Topics
- Amino Acid Sequence
- Animals
- Autoantibodies
- B7-1 Antigen
- CD4-Positive T-Lymphocytes
- CD40 Antigens
- Chronic Disease
- Epitopes, T-Lymphocyte
- Genetic Predisposition to Disease
- Immunization
- Injections, Subcutaneous
- Interferon-gamma
- Interleukin-4