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Article

Fatigue and muscle atrophy in a mouse model of myasthenia gravis is paralleled by loss of sarcolemmal nNOS.

PloS one - 1 Jan 2012

Meinen Sarina, Lin Shuo, Rüegg Markus A, Punga Anna Rostedt

Abstract excerpt

Myasthenia Gravis (MG) patients suffer from chronic fatigue of skeletal muscles, even after initiation of proper immunosuppressive medication. Since the localization of neuronal nitric oxide synthase (nNOS) at the muscle membrane is important for sustained muscle contraction, we here study the localization of nNOS in muscles from mice with acetylcholine receptor antibody seropositive (AChR+) experimental...

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Identifiers

PMID: 22952904
DOI: 10.1371/journal.pone.0044148
PMCID: PMC3429452

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