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Article

Ek alpha transgene in B10 mice suppresses the development of myasthenia gravis.

Immunogenetics - 1 Jan 1990

Christadoss P, David C S, Shenoy M, Keve S

Abstract excerpt

Mice bearing the H-2b haplotype are susceptible to the development of experimental autoimmune myasthenia gravis (EAMG), induced by acetylcholine receptor (AChR) autoimmunity. One of the genes influencing EAMG susceptibility has been mapped to the Ab locus of the major histocompatibility complex, and the A beta chain has been implicated in the pathogenesis. Mice of the H-2b haplotype, including C57BL/10 (B10),...

Topics

Animals
Antigens, Surface
Binding Sites
Chromosome Deletion
Genes, MHC Class II
Genetic Predisposition to Disease
Mice
Mice, Inbred C57BL
Mice, Transgenic
Muscles
Myasthenia Gravis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Cholinergic

Source

Identifiers

PMID: 2109730
DOI: 10.1007/BF00204895

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2109730-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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