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Article

Transgenic expression of IL-10 in T cells facilitates development of experimental myasthenia gravis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2001

Ostlie N S, Karachunski P I, Wang W, Monfardini C, Kronenberg M, Conti-Fine B M

Abstract excerpt

Ab to the acetylcholine receptor (AChR) cause experimental myasthenia gravis (EMG). Th1 cytokines facilitate EMG, whereas Th2 cytokines might be protective. IL-10 inhibits Th1 responses but facilitates B cell proliferation and Ig production. We examined the role of IL-10 in EMG by using wild-type (WT) C57BL/6 mice and transgenic (TG) C57BL/6 mice that express IL-10 under control of the IL-2 promoter. We immunized...

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PMID: 11290761
DOI: 10.4049/jimmunol.166.8.4853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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