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Immunization of mice with LRP4 induces myasthenia similar to MuSK-associated myasthenia gravis

18 Aug 2017

Abstract excerpt

Since the first report of experimental animal models of myasthenia gravis (MG) with autoantibodies against low-density lipoprotein receptor-related protein 4 (LRP4), there have not been any major reports replicating the pathogenicity of anti-LRP4 antibodies (Abs). Recent clinical studies have cast doubt on the specificity and pathogenicity of anti-LRP4 antibodies for MG, highlighting the need for further...

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PMID: 28823823
DOI: 10.1016/j.expneurol.2017.08.006

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