Article
Major histocompatibility complex class II gene disruption prevents experimental autoimmune myasthenia gravis.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1994
Kaul R, Shenoy M, Goluszko E, Christadoss P
Abstract excerpt
To analyze the impact of lack of MHC class II gene expression, and to demonstrate the direct genetic evidence for the involvement of the MHC class II gene product in the development of experimental autoimmune myasthenia gravis (EAMG), MHC class II gene-disrupted C57BL6 mutant (-/-) and EAMG-susceptible MHC class II wild-type C57BL6 mice (+/+) were evaluated for the clinical and immunopathologic manifestations of...
Topics
- Animals
- Autoantibodies
- CD4 Antigens
- Genes, MHC Class II
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- Mutation
- Myasthenia Gravis
- Receptors, Cholinergic
- T-Lymphocytes