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Article

Characterization of a Cul9-Parkin double knockout mouse model for Parkinson's disease.

Scientific reports - 9 Oct 2020

Hollville Emilie, Joers Valerie, Nakamura Ayumi, Swahari Vijay, Tansey Malú G, Moy Sheryl S, Deshmukh Mohanish

Abstract excerpt

Mitochondrial quality control is essential for the long-term survival of postmitotic neurons. The E3 ubiquitin ligase Parkin promotes the degradation of damaged mitochondria via mitophagy and mutations in Parkin are a major cause of early-onset Parkinson's disease (PD). Surprisingly however, mice deleted for Parkin alone are rather asymptomatic for PD-related pathology, suggesting that other complementary or...

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Source

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Identifiers

PMID: 33037272
DOI: 10.1038/s41598-020-73854-y
PMCID: PMC7547682

Genes

CUL9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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