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Article

Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1.

Molecular and cellular biology - 1 Sept 2013

Ekholm-Reed Susanna, Goldberg Matthew S, Schlossmacher Michael G, Reed Steven I

Abstract excerpt

Parkinson's disease (PD) is characterized by progressive loss of midbrain dopaminergic neurons resulting in motor dysfunction. While most PD is sporadic in nature, a significant subset can be linked to either dominant or recessive germ line mutations. PARK2, encoding the ubiquitin ligase parkin, is the most frequently mutated gene in hereditary Parkinson's disease. Here, we present evidence for a neuronal...

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Identifiers

PMID: 23858059
DOI: 10.1128/MCB.00535-13
PMCID: PMC3753862

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