Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Jan 2007

Sang Tzu-Kang, Chang Hui-Yun, Lawless George M, Ratnaparkhi Anuradha, Mee Lisa, Ackerson Larry C, Maidment Nigel T, Krantz David E, Jackson George R

Abstract excerpt

Mutations in human parkin have been identified in familial Parkinson's disease and in some sporadic cases. Here, we report that expression of mutant but not wild-type human parkin in Drosophila causes age-dependent, selective degeneration of dopaminergic (DA) neurons accompanied by a progressive motor impairment. Overexpression or knockdown of the Drosophila vesicular monoamine transporter, which regulates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Cell Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine

Share to Drosophila

Share to Drosophila Proteins

Share to Nerve Degeneration

Share to Neurons

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 17267552
DOI: 10.1523/JNEUROSCI.4810-06.2007
PMCID: PMC6673194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine.PMID 17267552Read ↗

Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.Semantic proximity Read ↗

Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged miceSemantic proximity Read ↗

Mitochondrial dysfunction and Parkinson's disease genes: insights from Drosophila.Semantic proximity Read ↗

Vulnerable Parkin Loss-of-Function Drosophila Dopaminergic Neurons Have Advanced Mitochondrial Aging, Mitochondrial Network Loss and Transiently Reduced Autophagosome RecruitmentSemantic proximity Read ↗

Analysis of α-syn and parkin interaction in mediating neuronal death in Drosophila model of Parkinson's diseaseSemantic proximity Read ↗

Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic StrategiesSemantic proximity Read ↗

Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.Semantic proximity Read ↗

PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiencySemantic proximity Read ↗

parkin counteracts symptoms in a Drosophila model of Parkinson's diseaseSemantic proximity Read ↗

Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.Semantic proximity Read ↗

Parkin R274W mutation affects muscle and mitochondrial physiology.Semantic proximity Read ↗

Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.