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Article

Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.

Neurobiology of aging - 1 Nov 2014

Oliveras-Salvá Marusela, Macchi Francesca, Coessens Valérie, Deleersnijder Angélique, Gérard Melanie, Van der Perren Anke, Van den Haute Chris, Baekelandt Veerle

Abstract excerpt

Loss-of-function mutations in the PINK1 gene lead to recessive forms of Parkinson's disease. Animal models with depleted PINK1 expression have failed to reproduce significant nigral dopaminergic neurodegeneration and clear alpha-synuclein pathology, main characteristics of the disease. In this study, we investigated whether alpha-synuclein pathology is altered in the absence of PINK1 in cell culture and in vivo....

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Source

Identifiers

PMID: 25037286
DOI: 10.1016/j.neurobiolaging.2014.04.032

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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