Article
Pharmacokinetic modelling of morphine, morphine-3-glucuronide and morphine-6-glucuronide in plasma and cerebrospinal fluid of neurosurgical patients after short-term infusion of morphine.
British journal of clinical pharmacology - 1 Dec 2002
Meineke Ingolf, Freudenthaler Stefan, Hofmann Ute, Schaeffeler Elke, Mikus Gerd, Schwab Matthias, Prange Hilmar W, Gleiter Christoph H, Brockmöller J
Abstract excerpt
AIMS: Concentrations in the cerebrospinal fluid (CSF) are a useful approximation to the effect site for drugs like morphine. However, CSF samples, are available only in rare circumstances. If they can be obtained they may provide important insights into the pharmacokinetics/pharmacodynamics of opioids. METHODS: Nine neurological and neurosurgical patients (age 19-69 years) received 0.5 mg kg-1 morphine sulphate...
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