Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Morphine 6beta glucuronide: fortuitous morphine metabolite or preferred peripheral regulatory opiate?

Medical science monitor : international medical journal of experimental and clinical research - 1 May 2005

Mantione Kirk J, Goumon Yannick, Esch Tobias, Stefano George B

Abstract excerpt

Morphine-6beta-glucuronide (M6G), a metabolite of morphine that the brain can produce, is an opiate agonist that appears to have a greater analgesic potency than morphine. M6G has a 1-octanol/water partition coefficient 187 times lower than that of morphine and M6G has a blood brain barrier permeability 57 times lower than morphine. The brain uptake rate however is only 32 times lower, suggesting that an active...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eating

Share to Morphine

Share to Motor Activity

Share to Peripheral Nervous System

Share to Receptors, Opioid, mu

Share to Signal Transduction

Source

Identifiers

PMID: 15874899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Morphine 6beta glucuronide: fortuitous morphine metabolite or preferred peripheral regulatory opiate?PMID 15874899Read ↗

Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?Semantic proximity Read ↗

The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine.Semantic proximity Read ↗

Pharmacogenomics and Morphine.Semantic proximity Read ↗

Variations in critical morphine biosynthesis genes and their potential to influence human health.Semantic proximity Read ↗

The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease.Semantic proximity Read ↗

Consequences of the 118A&gt;G polymorphism in the OPRM1 gene: translation from bench to bedside?Semantic proximity Read ↗

Reviewing pharmacogenetics to advance precision medicine for opioidsSemantic proximity Read ↗

Relevance of frequent mu-opioid receptor polymorphisms for opioid activity in healthy volunteers.Semantic proximity Read ↗

Variability in UDP-glucuronosyltransferase genes and morphine metabolism: observations from a cross-sectional multicenter study in advanced cancer patients with pain.Semantic proximity Read ↗

Opioids for chronic pain: molecular and genomic basis of actions and adverse effects.Semantic proximity Read ↗

Pharmacogenetics of Opioid ResponseSemantic proximity Read ↗

Association of the OPRM1 variant rs1799971 (A118G) and clinical manifestations in tramadol poisoned patients: a cross-sectional study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.