Article
Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy.
European journal of clinical pharmacology - 1 Aug 2002
Holthe Monica, Klepstad Pål, Zahlsen Kolbjørn, Borchgrevink Petter C, Hagen Lars, Dale Ola, Kaasa Stein, Krokan Hans E, Skorpen Frank
Abstract excerpt
OBJECTIVE: UDP-glucuronosyltransferase (UGT) 2B7 is the major UGT isoform responsible for the 3- and 6-glucuronidation of morphine in humans. Studies in rats have indicated that UGT1A1 may also contribute to the formation of morphine 3-glucuronide (M3G). Our objective was to investigate whether the UGT2B7 H268Y and UGT1A1*28 polymorphisms contribute to the variability in morphine glucuronide-to-morphine plasma...
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