Article
Impact of CYP3A5*3 on plasma exposure and urinary excretion of fentanyl and norfentanyl in the early postsurgical period.
Therapeutic drug monitoring - 1 Jun 2014
Tanaka Noriaki, Naito Takafumi, Yagi Tatsuya, Doi Matsuyuki, Sato Shigehito, Kawakami Junichi
Abstract excerpt
BACKGROUND: The pharmacokinetic characteristics of intravenous fentanyl have not been fully clarified in the early postsurgical period. The aim of this study was to evaluate the plasma exposure and urinary excretion of fentanyl and norfentanyl according to cytochrome P450 (CYP) 3A5 genetic polymorphism. METHODS: Fifty-two adult Japanese postoperative patients receiving a continuous intravenous fentanyl infusion...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.