Article

Nonlinear blood-brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix.

2023-05-31

Abstract excerpt

<h4>Background: </h4> & purpose Morphine is important for treatment of acute and chronic pain. However, there is high interpatient variability and often inadequate pain relief and adverse effects. To better understand variability in the dose effect relationships of morphine, we investigated the impact of its nonlinear blood-brain-barrier (BBB) transport on mu-opioid receptor (μ-OR) occupancy in different CNS locat...

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Literature Corpus work: 291f7923-2482-5ec0-b4d5-23eda58e7196
DOI: 10.22541/au.168551715.56337335/v1

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