Article
Pharmacokinetics of intravenous and oral midazolam in plasma and saliva in humans: usefulness of saliva as matrix for CYP3A phenotyping.
British journal of clinical pharmacology - 1 Oct 2008
Link Bettina, Haschke Manuel, Grignaschi Nathalie, Bodmer Michael, Aschmann Yvonne Zysset, Wenk Markus, Krähenbühl Stephan
Abstract excerpt
AIMS: To compare midazolam kinetics between plasma and saliva and to find out whether saliva is suitable for CYP3A phenotyping. METHODS: This was a two way cross-over study in eight subjects treated with 2 mg midazolam IV or 7.5 mg orally under basal conditions and after CYP3A induction with rifampicin. RESULTS: Under basal conditions and IV administration, midazolam and 1'-hydroxymidazolam (plasma, saliva),...
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