Effect of UGT2B7 -900G>A (-842G>A; rs7438135) on morphine glucuronidation in preterm newborns: results from a pilot cohort.

doi:10.2217/pgs.14.115

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Article

Effect of UGT2B7 -900G>A (-842G>A; rs7438135) on morphine glucuronidation in preterm newborns: results from a pilot cohort.

Pharmacogenomics - 1 Jan 2014

Matic Maja, Norman Elisabeth, Rane Anders, Beck Olof, Andersson Maria, Elens Laure, Tibboel Dick, Fellman Vineta, van Schaik Ron H N

Abstract excerpt

AIM: Assess association between UGT2B7 polymorphism -900G>A (rs7438135, also known as -842G>A) with morphine kinetics in preterm newborns undergoing mechanical ventilation. MATERIALS & METHODS: Thirty-four infants were enrolled in a randomized clinical trial and allocated to rapid sequence intubation with remifentanil (1 µg/kg) or morphine (0.3 mg/kg). The latter group was included in our study. RESULTS: Morphine...

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PMID: 25340733
DOI: 10.2217/pgs.14.115

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