Article
Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 1994
Provost G S, Short J M
Abstract excerpt
Transgenic B6C3F1 mice carrying a lacI target gene were exposed to acute and multiple doses of ethylnitrosourea (ENU), and germ cells from the seminiferous tubules were assayed for mutation 3 and 90 days after treatment. Relative to untreated controls, the mutation frequency increased 3.2- and 19...
Topics
- Animals
- Base Composition
- Crosses, Genetic
- DNA
- Ethylnitrosourea
- Female
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Mice, Transgenic
- Mutagenesis
- Mutation
- Point Mutation
- Repetitive Sequences, Nucleic Acid
- Seminiferous Tubules
- Sequence Deletion