Article
A comparative study of in vivo mutation assays: analysis of hprt, lacI, cII/cI and as mutational targets for N-nitroso-N-methylurea and benzo[a]pyrene in Big Blue mice.
Mutation research - 12 Oct 1998
Monroe J J, Kort K L, Miller J E, Marino D R, Skopek T R
Abstract excerpt
We have compared the response of the native hprt gene and the lacI, cII, and cI transgenes in Big Blue B6C3F1 mice following treatment with either N-nitroso-N-methylurea (MNU) or benzo[a]pyrene (BaP). Three weeks after mutagen treatment splenic T cells were isolated from the animals, and samples...
Topics
- Animals
- Bacterial Proteins
- Bacteriophage lambda
- Benzo(a)pyrene
- DNA Mutational Analysis
- DNA-Binding Proteins
- Escherichia coli
- Escherichia coli Proteins
- Hypoxanthine Phosphoribosyltransferase
- Lac Repressors
- Methylnitrosourea
- Mice
- Mice, Transgenic
- Mutagenicity Tests
- Mutagens
- Mutation
- Repressor Proteins
- Sensitivity and Specificity