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Article

Mutations induced in male germ cells after treatment of transgenic mice with ethylnitrosourea.

Mutation research - 14 Feb 1997

Katoh M, Horiya N, Valdivia R P

Abstract excerpt

The present study was undertaken to clarify whether the transgenic mouse mutagenesis assay system can be used instead of dominant lethals or specific locus test after treatment of male germ cells in mouse with ethylnitrosourea (ENU). Male Big Blue transgenic mice (BB) carrying a lacI target gene were given a single intraperitoneal injection of 150 mg/kg ENU. Vasa deferential sperm, caudal epididymal sperm or...

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PMID: 9057885
DOI: 10.1016/s1383-5718(96)00121-0

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Mutations induced in male germ cells after treatment of transgenic mice with ethylnitrosourea.PMID 9057885Read ↗

Studies on mutations in male germ cells of transgenic mice following exposure to isopropyl methanesulfonate, ethylnitrosourea or X-ray.Semantic proximity Read ↗

Transmission of mutations in the lacI transgene to the offspring of ENU-treated Big Blue male mice.Semantic proximity Read ↗

The induction of forward and reverse specific-locus mutations and dominant cataract mutations in spermatogonia of treated strain DBA/2 mice by ethylnitrosourea.Semantic proximity Read ↗

The frequency of dominant cataract and recessive specific-locus mutations and mutation mosaics in F1 mice derived from post-spermatogonial treatment with ethylnitrosourea.Semantic proximity Read ↗

Genetic analysis of an N-ethyl-N-nitrosourea-induced mutation at the hemoglobin beta-chain locus in mice.Semantic proximity Read ↗

Comparison of mutation frequencies obtained using transgenes and specific-locus mutation systems in male mouse germ cells.Semantic proximity Read ↗

Temporal and molecular characteristics of mutations induced by ethylnitrosourea in germ cells isolated from seminiferous tubules and in spermatozoa of lacZ transgenic mice.Semantic proximity Read ↗

Effects of O (6)-alkylguanine-DNA alkyltransferase deficiency in Escherichia coli as the host for the detection of mutations in lacI transgenic mice.Semantic proximity Read ↗

Induction of specific-locus and dominant lethal mutations in male mice by 1-methyl-1-nitrosourea (MNU).Semantic proximity Read ↗

Organ variation in the mutagenicity of ethylnitrosourea in Muta mouse: results of the collaborative study on the transgenic mutation assay by JEMS/MMS. The Collaborative Study Group for the Transgenic Mouse Mutation Assay Mammalian Mutagenesis Study Group of the Environmental Mutagen Society of Japan.Semantic proximity Read ↗

[Studies on gene mutation and micronucleus formation induced by ethylnitrosourea (ENU) in transgenic mice in vivo].Semantic proximity Read ↗

Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice.Semantic proximity Read ↗

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