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Article

Activator-independent functions of the yeast mediator sin4 complex in preinitiation complex formation and transcription reinitiation.

Molecular and cellular biology - 1 Jan 2003

Reeves Wendy M, Hahn Steven

Abstract excerpt

RNA polymerase II (Pol II) Mediator plays an essential role in both basal and activated transcription. Previously, subunits of the Sin4 Mediator complex (Sin4, Pgd1, Gal11, and Med2) have been implicated in both positive and negative transcriptional regulation. Furthermore, it was proposed that this subcomplex constitutes an activator-binding domain. A yeast nuclear-extract system was used to investigate the...

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Identifiers

PMID: 12482986
DOI: 10.1128/MCB.23.1.349-358.2003
PMCID: PMC140685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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