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Article

The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions.

Molecular and cellular biology - 1 Jan 2003

Perrin Laurent, Bloyer Sébastien, Ferraz Conchita, Agrawal Namita, Sinha Pradip, Dura Jean Maurice

Abstract excerpt

In a screen for Drosophila genes that interfere with transcriptional repression mediated by the Polycomb group of genes, we identified a dominant mutation affecting the Alhambra (Alh) gene, the fly homologue of the human AF10 gene. AF10 has been identified as a fusion partner of both MLL and CALM in infant leukemias. Both fusion proteins retain the leucine zipper domain of AF10 but not its PHD domain. We show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myeloid-Lymphoid Leukemia Protein

Share to Oncogene Proteins, Fusion

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Identifiers

PMID: 12482966
DOI: 10.1128/MCB.23.1.119-130.2003
PMCID: PMC140655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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