Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10

15 May 2002

Abstract excerpt

The t(10;11)(p12;q23) chromosomal translocation in human acute myeloid leukemia results in the fusion of the MLL and AF10 genes. The latter codes for a novel leucine zipper protein, one of many MLL fusion partners of unknown function. In this report, we demonstrate that retroviral-mediated transduction of an MLL-AF10 complementary DNA into primary murine myeloid progenitors enhanced their clonogenic potential in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Genomics and Chromatin Dynamics
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11986236
DOI: 10.1182/blood.v99.10.3780

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10PMID 11986236Read ↗

A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AMLSemantic proximity Read ↗

A JAK/STAT-Mediated Inflammatory Signaling Cascade Drives Oncogenesis In AF10-Rearranged AMLSemantic proximity Read ↗

The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.Semantic proximity Read ↗

The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis.Semantic proximity Read ↗

The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitmentSemantic proximity Read ↗

MLL-AF9 leukemia stem cells: hardwired or taking cues from the microenvironment?Semantic proximity Read ↗

Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice.Semantic proximity Read ↗

MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function.Semantic proximity Read ↗

Post-transcriptional gene regulation by the RNA binding protein IGF2BP3 is critical for MLL-AF4 mediated leukemogenesisSemantic proximity Read ↗

The AF4·MLL fusion protein is capable of inducing ALL in mice without requirement of MLL·AF4Semantic proximity Read ↗

C/EBPα: critical at the origin of leukemic transformationSemantic proximity Read ↗

Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.