Article
Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia.
Blood - 1 Mar 2004
Kumar Ashish R, Hudson Wendy A, Chen Weili, Nishiuchi Ritsuo, Yao Qing, Kersey John H
Abstract excerpt
Identification of the targets of mixed lineage leukemia (MLL) fusion genes will assist in understanding the biology of MLL fusion gene leukemias and in development of better therapies. Numerous studies have implicated HOXA9 as one of the possible targets of MLL fusion proteins. To determine if HOXA9 was required for leukemia development by MLL fusion genes, we compared the effects of the Mll-AF9 knock-in mutation...
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