The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia.

doi:10.3324/haematol.2012.074195

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Article

The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia.

Haematologica - 1 Jun 2013

Thiel Austin T, Feng Zijie, Pant Dhruv K, Chodosh Lewis A, Hua Xianxin

Abstract excerpt

Trithorax and polycomb group proteins antagonistically regulate the transcription of many genes, and cancer can result from the disruption of this regulation. Deregulation of trithorax function occurs through chromosomal translocations involving the trithorax gene MLL, leading to the expression of MLL fusion proteins and acute leukemia. It is poorly understood how MLL fusion proteins block differentiation, a...

Topics

Animals
CCAAT-Enhancer-Binding Protein-alpha
Cell Differentiation
Cell Line
Enhancer of Zeste Homolog 2 Protein
Gene Expression Regulation, Leukemic
Gene Knockdown Techniques
Genotype
Humans
Leukemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Myeloid-Lymphoid Leukemia Protein

Oncogene Proteins, Fusion

Polycomb Repressive Complex 2

Protein Binding

Proto-Oncogene Proteins

Transcriptional Activation

Source

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Identifiers

PMID: 23349306
DOI: 10.3324/haematol.2012.074195
PMCID: PMC3669449

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