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Article

The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis.

The EMBO journal - 1 Jul 1999

Dobson C L, Warren A J, Pannell R, Forster A, Lavenir I, Corral J, Smith A J, Rabbitts T H

Abstract excerpt

The MLL gene from human chromosome 11q23 is involved in >30 different chromosomal translocations resulting in a plethora of different MLL fusion proteins. Each of these tends to associate with a specific leukaemia type, for example, MLL-AF9 is found mainly in acute myeloid leukaemia. We have studied the role of the Mll-AF9 gene fusion made in mouse embryonic stem cells by an homologous recombination knock-in....

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Share to Bone Marrow Cells
Share to Histone-Lysine N-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Myeloid-Lymphoid Leukemia Protein

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Share to Translocation, Genetic

Source

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Identifiers

PMID: 10393173
DOI: 10.1093/emboj/18.13.3564
PMCID: PMC1171435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis.PMID 10393173Read ↗

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