Perspectives for identification of mutations in the zebrafish: making use of next-generation sequencing technologies for forward genetic approaches.

Abstract excerpt

The ability to identify a phenotype causing mutation is essential for successful use of mutagenesis screens in many model organisms. Mapping mutations was for a long time a bottleneck in zebrafish research, as the standard method for mapping and identification of mutations was time consuming and expensive. The development of new sequencing technologies in the last couple of years has enabled the rapid and...

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• Algorithms
• Chromosomes
• Genetic Linkage
• Genome
• High-Throughput Nucleotide Sequencing