Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Positional identification of Ncf1 as a gene that regulates arthritis severity in rats.

Nature genetics - 1 Jan 2003

Olofsson Peter, Holmberg Jens, Tordsson Jesper, Lu Shemin, Akerström Bo, Holmdahl Rikard

Abstract excerpt

The identification of genes underlying quantitative-trait loci (QTL) for complex diseases, such as rheumatoid arthritis, is a challenging and difficult task for the human genome project. Through positional cloning of the Pia4 QTL in rats, we found that a naturally occurring polymorphism of Ncf1 (...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoptive Transfer
Share to Animals, Congenic
Share to Animals, Wild

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis

Share to NADPH Oxidases

Share to Physical Chromosome Mapping

Share to Rats, Inbred Strains

Share to Respiratory Burst

Source

Identifiers

PMID: 12461526
DOI: 10.1038/ng1058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12461526-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Positional identification of Ncf1 as a gene that regulates arthritis severity in rats.PMID 12461526Read ↗

Positional cloning of Ncf1--a piece in the puzzle of arthritis genetics.Semantic proximity Read ↗

Finding causative genes underlying rheumatic disease: could NCF1 pave the way?Semantic proximity Read ↗

Copy number variation of the gene NCF1 is associated with rheumatoid arthritis.Semantic proximity Read ↗

Quest for arthritis-causative genetic factors in the rat.Semantic proximity Read ↗

Advanced intercross line mapping suggests that ncf1 (ean6) regulates severity in an animal model of guillain-barre syndrome.Semantic proximity Read ↗

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity.Semantic proximity Read ↗

Definition of arthritis candidate risk genes by combining rat linkage-mapping results with human case-control association data.Semantic proximity Read ↗

High resolution mapping of an arthritis susceptibility locus on rat chromosome 4, and characterization of regulated phenotypes.Semantic proximity Read ↗

Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1.Semantic proximity Read ↗

Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.Semantic proximity Read ↗

Identification of candidate risk gene variations by whole-genome sequence analysis of four rat strains commonly used in inflammation research.Semantic proximity Read ↗

Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.