Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats.

Antioxidants & redox signaling - 15 Jun 2011

Hultqvist Malin, Sareila Outi, Vilhardt Frederik, Norin Ulrika, Olsson Lina M, Olofsson Peter, Hellman Ulf, Holmdahl Rikard

Abstract excerpt

The Ncf1 gene, encoding the P47(PHOX) protein that regulates production of reactive oxygen species (ROS) by the phagocyte NADPH oxidase (NOX2) complex, is associated with autoimmunity and arthritis severity in rats. We have now identified that the single-nucleotide polymorphism (SNP) resulting in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis
Share to Chlorocebus aethiops
Share to COS Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NADPH Oxidases

Share to Phagosomes

Share to Rats, Wistar

Share to Reactive Oxygen Species

Share to Respiratory Burst

Source

Identifiers

PMID: 21275845
DOI: 10.1089/ars.2010.3440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21275845-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats.PMID 21275845Read ↗

Positional identification of Ncf1 as a gene that regulates arthritis severity in rats.Semantic proximity Read ↗

Association of NOX2 subunits genetic variants with autoimmune diseases.Semantic proximity Read ↗

Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1.Semantic proximity Read ↗

Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.Semantic proximity Read ↗

Positional cloning of Ncf1--a piece in the puzzle of arthritis genetics.Semantic proximity Read ↗

Lack of reactive oxygen species breaks T cell tolerance to collagen type II and allows development of arthritis in mice.Semantic proximity Read ↗

Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.Semantic proximity Read ↗

Reactive oxygen species (ROS), but not nitric oxide (NO), contribute to strain differences in the susceptibility to experimental arthritis in rats.Semantic proximity Read ↗

Lack of p47(phox) in Akita Diabetic Mice Is Associated with Interstitial Pneumonia, Fibrosis, and Oral Inflammation.Semantic proximity Read ↗

A glucose-6-phosphate isomerase peptide induces T and B cell-dependent chronic arthritis in C57BL/10 mice: arthritis without reactive oxygen species and complement.Semantic proximity Read ↗

Redox Regulation of LAT Enhances T Cell-Mediated InflammationSemantic proximity Read ↗

Detection of arthritis-susceptibility loci, including Ncf1, and variable effects of the major histocompatibility complex region depending on genetic background in rats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.