Article
Definition of arthritis candidate risk genes by combining rat linkage-mapping results with human case-control association data.
Annals of the rheumatic diseases - 1 Dec 2009
Bäckdahl L, Guo J P, Jagodic M, Becanovic K, Ding B, Olsson T, Lorentzen J C
Abstract excerpt
OBJECTIVE: To define genomic regions that link to rat arthritis and to determine the potential association with rheumatoid arthritis (RA) of the corresponding human genomic regions. METHODS: Advanced intercross lines (AIL) between arthritis susceptible DA rats and arthritis resistant PVG.1AV1 rats were injected with differently arthritogenic oils to achieve an experimental situation with substantial phenotypic...
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