Article
High resolution mapping of an arthritis susceptibility locus on rat chromosome 4, and characterization of regulated phenotypes.
Human molecular genetics - 1 Sept 2003
Ribbhammar Ulrica, Flornes Line, Bäckdahl Liselotte, Luthman Holger, Fossum Sigbjörn, Lorentzen Johnny C
Abstract excerpt
The rat Natural Killer cell gene Complex (NKC) encodes molecules that can regulate immunity. It is located within an interval on DA rat chromosome 4 (RNO4) that is linked to immune-mediated inflammatory joint diseases, including oil-induced arthritis (OIA). We aimed to test the hypothesis that NKC regulates arthritis, by performing advanced mapping of arthritis and additional phenotypes induced by an intradermal...
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