Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Copy number variation of the gene NCF1 is associated with rheumatoid arthritis.

Antioxidants & redox signaling - 1 Jan 2012

Olsson Lina M, Nerstedt Annika, Lindqvist Anna-Karin, Johansson Sa C M, Medstrand Patrik, Olofsson Peter, Holmdahl Rikard

Abstract excerpt

AIMS: The aim of this study was to investigate genetic variants in the gene neutrophil cytosolic factor 1 (NCF1) for association with rheumatoid arthritis (RA). In rodent models, a single-nucleotide polymorphism (SNP) in Ncf1 has been shown to be a major locus regulating severity of arthritis. Ncf1 encodes one of five subunits of the NADPH oxidase complex. In humans the genomic structure of NCF1 is complex,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Dosage
Share to Gene Order

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis, Rheumatoid

Share to Case-Control Studies

Share to DNA Copy Number Variations

Share to NADPH Oxidases

Share to Reactive Oxygen Species

Share to Young Adult

Source

Identifiers

PMID: 21728841
DOI: 10.1089/ars.2011.4013

Genes

NCF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Copy number variation of the gene NCF1 is associated with rheumatoid arthritis.PMID 21728841Read ↗

Finding causative genes underlying rheumatic disease: could NCF1 pave the way?Semantic proximity Read ↗

Positional identification of Ncf1 as a gene that regulates arthritis severity in rats.Semantic proximity Read ↗

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity.Semantic proximity Read ↗

A copy number variation in human NCF1 and its pseudogenes.Semantic proximity Read ↗

Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.Semantic proximity Read ↗

Association of NCF2, NCF4, and CYBA Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population.Semantic proximity Read ↗

Association of NOX2 subunits genetic variants with autoimmune diseases.Semantic proximity Read ↗

A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases.Semantic proximity Read ↗

Neutrophil cytosolic factor 2 (NCF2) gene polymorphism is associated with juvenile-onset systemic lupus erythematosus, but probably not with other autoimmune rheumatic diseases in children.Semantic proximity Read ↗

Positional cloning of Ncf1--a piece in the puzzle of arthritis genetics.Semantic proximity Read ↗

Copy number variation in autoimmunity--importance hidden in complexity?Semantic proximity Read ↗

Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.