Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Finding causative genes underlying rheumatic disease: could NCF1 pave the way?

Annals of the rheumatic diseases - 1 Jul 2026

Holmdahl Rikard, Tsao Betty P

Abstract excerpt

The identification of genetic risk factors could facilitate our understanding of the cause and pathogenesis of rheumatic diseases. Maps of susceptibility loci have been established for most complex diseases, including all major rheumatic diseases, but definitive causal variants have been identified only very infrequently. Here, we highlight the need to both position and confirm the role of causative polymorphisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Linkage Disequilibrium
Share to NADPH Oxidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Rheumatic Diseases

Source

Identifiers

PMID: 41956840
DOI: 10.1016/j.ard.2026.02.022

Genes

NCF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Finding causative genes underlying rheumatic disease: could NCF1 pave the way?PMID 41956840Read ↗

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity.Semantic proximity Read ↗

Copy number variation of the gene NCF1 is associated with rheumatoid arthritis.Semantic proximity Read ↗

Positional identification of Ncf1 as a gene that regulates arthritis severity in rats.Semantic proximity Read ↗

A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases.Semantic proximity Read ↗

Association of NOX2 subunits genetic variants with autoimmune diseases.Semantic proximity Read ↗

Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.Semantic proximity Read ↗

Positional cloning of Ncf1--a piece in the puzzle of arthritis genetics.Semantic proximity Read ↗

Neutrophil cytosolic factor 2 (NCF2) gene polymorphism is associated with juvenile-onset systemic lupus erythematosus, but probably not with other autoimmune rheumatic diseases in children.Semantic proximity Read ↗

Use of next-generation DNA sequencing to analyze genetic variants in rheumatic disease.Semantic proximity Read ↗

Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.Semantic proximity Read ↗

Genetically transitional disease: conceptual understanding and applicability to rheumatic disease.Semantic proximity Read ↗

Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.