Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1.

Genomics - 1 May 2004

Olofsson Peter, Johansson Asa, Wedekind Dirk, Klöting Ingrid, Klinga-Levan Karin, Lu Shemin, Holmdahl Rikard

Abstract excerpt

We recently identified a single-nucleotide polymorphism in the Ncf1 gene, a component of the NADPH oxidase complex, to be the cause of one of the strongest identified loci for arthritis severity in rats. This polymorphism was found to be naturally occurring in a collection of inbred rat strains as well as in wild rats. Among the inbred strains we found that different LEW substrains (LEW/Ztm and LEW/Mol),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to Autoimmunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Mammalian

Share to Hybridization, Genetic

Share to NADPH Oxidases

Share to Rats, Inbred Lew

Share to Reactive Oxygen Species

Share to Terpenes

Source

Identifiers

PMID: 15081107
DOI: 10.1016/j.ygeno.2003.10.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1.PMID 15081107Read ↗

Positional identification of Ncf1 as a gene that regulates arthritis severity in rats.Semantic proximity Read ↗

Positional cloning of Ncf1--a piece in the puzzle of arthritis genetics.Semantic proximity Read ↗

Quest for arthritis-causative genetic factors in the rat.Semantic proximity Read ↗

Detection of arthritis-susceptibility loci, including Ncf1, and variable effects of the major histocompatibility complex region depending on genetic background in rats.Semantic proximity Read ↗

Association of NOX2 subunits genetic variants with autoimmune diseases.Semantic proximity Read ↗

Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.Semantic proximity Read ↗

Primer: comparative genetics of animal models of arthritis--a tool to resolve complexity.Semantic proximity Read ↗

Lack of reactive oxygen species breaks T cell tolerance to collagen type II and allows development of arthritis in mice.Semantic proximity Read ↗

Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats.Semantic proximity Read ↗

Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies.Semantic proximity Read ↗

Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.Semantic proximity Read ↗

Finding causative genes underlying rheumatic disease: could NCF1 pave the way?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.