Article
Positional cloning of Ncf1--a piece in the puzzle of arthritis genetics.
Scandinavian journal of immunology - 1 Aug 2003
Olofsson P, Holmdahl R
Abstract excerpt
Positional cloning of susceptibility genes in complex diseases like rheumatoid arthritis in humans is hampered by aspects like genetic heterogeneity and environmental variations, while genetic studies in animal models contain several advantages. With animal models, the environment can be controlled, the genetic complexity of the disease is minimized and the disease onset can be predicted, which simplify diagnosis...
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