Article
Engineering S-protein fragments of bovine ribonuclease A for targeted drug delivery.
Protein expression and purification - 1 Dec 2002
Backer Marina V, Gaynutdinov Timur I, Aloise Renee, Przekop Kristen, Backer Joseph M
Abstract excerpt
High affinity interaction between S-protein and S-peptide fragments of bovine pancreatic RNase A has been recently used for construction of molecular vehicles for targeted drug delivery. The vehicle is assembled as a complex of drug carrier conjugated S-protein with S-peptide-tagged targeting protein. To avoid random chemical crosslinking of drug carriers to S-protein, we constructed a mutant 16-124aa fragment of...
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