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Article

Significant stabilization of ribonuclease A by additive effects.

The FEBS journal - 1 Jul 2012

Arnold Ulrich, Schöpfel Michael

Abstract excerpt

Among the strategies that employ genetic engineering to stabilize proteins, the introduction of disulfide bonds has proven to be a very potential approach. As, however, the replacement of amino acid residues by cysteines and the subsequent formation of the covalent bond can result in a severe deformation of the parental protein structure, the stabilization effect is strongly context dependent. Alternatively, the...

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Source

Identifiers

PMID: 22594773
DOI: 10.1111/j.1742-4658.2012.08632.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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