Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chimeric ribonuclease as a source of human adapter protein for targeted drug delivery.

Protein engineering - 1 Oct 2003

Gaynutdinov Timur I, Myshkin Eugene, Backer Joseph M, Backer Marina V

Abstract excerpt

Assembled modular complexes for targeted drug delivery can be based on strong non-covalent interactions between a cargo module containing an adapter protein and a docking tag fused to a targeting protein. We have recently constructed a completely humanized adapter/docking tag system based on interactions between 15 amino acid (Hu-tag) and 110 amino acid (HuS) fragments of human ribonuclease I (RNase I). Although...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteriocins
Share to Chromatography, Affinity
Share to Drug Delivery Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endopeptidase K

Share to Peptides

Share to Protein Engineering

Share to Ribonuclease, Pancreatic

Share to Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 14600207
DOI: 10.1093/protein/gzg097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chimeric ribonuclease as a source of human adapter protein for targeted drug delivery.PMID 14600207Read ↗

A "dock and lock" approach to preparation of targeted liposomes.Semantic proximity Read ↗

Engineering S-protein fragments of bovine ribonuclease A for targeted drug delivery.Semantic proximity Read ↗

Engineering Human Pancreatic RNase 1 as an Immunotherapeutic Agent for Cancer Therapy Through Computational and Experimental Studies.Semantic proximity Read ↗

Human antibody RNase fusion protein targeting CD30+ lymphomasSemantic proximity Read ↗

Engineered human angiogenin mutations in the placental ribonuclease inhibitor complex for anticancer therapy: Insights from enhanced sampling simulations.Semantic proximity Read ↗

Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure.Semantic proximity Read ↗

<em>In Silico</em> Design of a Chimeric Humanized L-Asparaginase.Semantic proximity Read ↗

Angiogenin mutants as novel effector molecules for the generation of fusion proteins with increased cytotoxic potential.Semantic proximity Read ↗

Grafting synthetic transmembrane units to the engineered low-toxicity α-hemolysin to restore its hemolytic activity.Semantic proximity Read ↗

Linkers: a synergistic way for chimeric proteinsSemantic proximity Read ↗

Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases.Semantic proximity Read ↗

Tuning the serum persistence of human serum albumin domain III:diabody fusion proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.