Article
Grafting synthetic transmembrane units to the engineered low-toxicity α-hemolysin to restore its hemolytic activity.
Molecular bioSystems - 1 Dec 2014
Ui Mihoko, Harima Kousuke, Takei Toshiaki, Tsumoto Kouhei, Tabata Kazuhito V, Noji Hiroyuki, Endo Sumire, Akiyama Kimio, Muraoka Takahiro, Kinbara Kazushi
Abstract excerpt
The chemical modification of proteins to provide desirable functions and/or structures broadens their possibilities for use in various applications. Usually, proteins can acquire new functions and characteristics, in addition to their original ones, via the introduction of synthetic functional moieties. Here, we adopted a more radical approach to protein modification, i.e., the replacement of a functional domain...
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