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Article

Extensive deamidation of RNase A inhibits its oligomerization through 3D domain swapping.

Biochimica et biophysica acta. Proteins and proteomics - 1 Jan 2017

Fagagnini Andrea, Montioli Riccardo, Caloiu Andra, Ribó Marc, Laurents Douglas V, Gotte Giovanni

Abstract excerpt

Bovine pancreatic ribonuclease A (RNase A) is the monomeric prototype of the so-called secretory 'pancreatic-type' RNase super-family. Like the naturally domain-swapped dimeric bovine seminal variant, BS-RNase, and its glycosylated RNase B isoform, RNase A forms N- and C-terminal 3D domain-swapped oligomers after lyophilization from acid solutions, or if subjected to thermal denaturation at high protein...

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Identifiers

PMID: 27783927
DOI: 10.1016/j.bbapap.2016.10.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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