Article
A "dock and lock" approach to preparation of targeted liposomes.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010
Backer Marina V, Backer Joseph M
Abstract excerpt
We developed a strategy for covalent coupling of targeting proteins to liposomes decorated with a standard adapter protein. This strategy is based on "dock and lock" the interactions between two mutated fragments of human RNase I, a 1-15-aa fragment with the R4C amino acid substitution, (Cys-tag), and a 21-127-aa fragment with the V118C substitution, (Ad-C). Upon binding to each other, Cys-tag and Ad-C...
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