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Article

Mouse insulin cells expressing an inducible RIPCre transgene are functionally impaired.

The Journal of biological chemistry - 6 Feb 2015

Teitelman Gladys, Kedees Mamdouh

Abstract excerpt

We used cre-lox technology to test whether the inducible expression of Cre minimize the deleterious effect of the enzyme on beta cell function. We studied mice in which Cre is linked to a modified estrogen receptor (ER), and its expression is controlled by the rat insulin promoter (RIP). Following the injection of tamoxifen (TM), CreER- migrates to the nucleus and promotes the appearance of a reporter protein,...

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Identifiers

PMID: 25533471
DOI: 10.1074/jbc.M114.615484
PMCID: PMC4319030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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