Article
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.
Nature - 29 May 2003
Ueda Hironori, Howson Joanna M M, Esposito Laura, Heward Joanne, Snook Hywel, Chamberlain Giselle, Rainbow Daniel B, Hunter Kara M D, Smith Annabel N, Di Genova Gianfranco, Herr Mathias H, Dahlman Ingrid, Payne Felicity, Smyth Deborah, Lowe Christopher, Twells Rebecca C J, Howlett Sarah, Healy Barry, Nutland Sarah, Rance Helen E, Everett Vin, Smink Luc J, Lam Alex C, Cordell Heather J, Walker Neil M, Bordin Cristina, Hulme John, Motzo Costantino, Cucca Francesco, Hess J Fred, Metzker Michael L, Rogers Jane, Gregory Simon, Allahabadia Amit, Nithiyananthan Ratnasingam, Tuomilehto-Wolf Eva, Tuomilehto Jaakko, Bingley Polly, Gillespie Kathleen M, Undlien Dag E, Rønningen Kjersti S, Guja Cristian, Ionescu-Tîrgovişte Constantin, Savage David A, Maxwell A Peter, Carson Dennis J, Patterson Chris C, Franklyn Jayne A, Clayton David G, Peterson Laurence B, Wicker Linda S, Todd John A, Gough Stephen C L
Abstract excerpt
Genes and mechanisms involved in common complex diseases, such as the autoimmune disorders that affect approximately 5% of the population, remain obscure. Here we identify polymorphisms of the cytotoxic T lymphocyte antigen 4 gene (CTLA4)--which encodes a vital negative regulatory molecule of the immune system--as candidates for primary determinants of risk of the common autoimmune disorders Graves' disease,...
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