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Article

Polymorphisms in CD28, CTLA-4, CD80 and CD86 genes may influence the risk of multiple sclerosis and its age of onset.

Journal of neuroimmunology - 15 Nov 2015

Wagner Marta, Sobczyński Maciej, Karabon Lidia, Bilińska Małgorzata, Pokryszko-Dragan Anna, Pawlak-Adamska Edyta, Cyrul Małgorzata, Kuśnierczyk Piotr, Jasek Monika

Abstract excerpt

CD28/CTLA-4–CD80/CD86 molecules play an important role in the regulation of T cells activation. Defects in proteins involved in this pathway may lead to the development of autoimmune diseases in which T cells are involved. In this case–control study (336 multiple sclerosis (MS) patients and 322 controls) we investigated the possible association of eleven polymorphisms in CD28, CTLA-4, CD80 and CD86 genes with...

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Identifiers

PMID: 26531698
DOI: 10.1016/j.jneuroim.2015.09.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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