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Article

Contrasting genetic architectures of multiple sclerosis susceptibility and outcome phenotypes.

Revue neurologique - 1 May 2026

Sorella M Y, Ding Y, Garcia A M, Ygonia M, Wang L, Jacobs B M, Harroud A

Abstract excerpt

Multiple sclerosis (MS) is characterized by substantial clinical heterogeneity, yet the factors governing long-term outcomes remain poorly understood. Over the past two decades, genome-wide association studies have identified an increasing number of genetic variants influencing MS susceptibility, predominantly implicating immune pathways. Whether these same variants also shape disease course after onset is a...

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PMID: 41935914
DOI: 10.1016/j.neurol.2026.03.007

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